U6 snRNA m6A modification is required for accurate and efficient cis- and trans-splicing of C. elegans mRNAs Abstract pre-mRNA splicing is a critical feature of eukaryotic gene expression. Many eukaryotes use cis-splicing to remove intronic sequences from pre-mRNAs. In addition to cis-splicing, many organisms use trans-splicing to replace the 5′ ends of mRNAs with a …

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